Microsatellite instability in colitis associated colorectal cancer.
نویسنده
چکیده
منابع مشابه
Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers.
BACKGROUND Ulcerative colitis is associated with an increased risk of colorectal cancer above that of the normal population. The relative risk correlates with the extent and duration of the disease but the genetic basis of ulcerative colitis associated cancer risk is not known. AIMS To assess the prevalence of microsatellite instability and mismatch repair gene abnormalities in ulcerative col...
متن کاملMolecular Genetics of Ulcerative Colitis-associated Colon Cancer in the Interleukin
Mice deficient in 2-microglobulin and interleukin 2 ( 2m null IL2) spontaneously develop colon cancer in the setting of chronic ulcerative colitis (UC). We investigated mutations of the Apc and p53 genes and microsatellite instability in colonic adenocarcinomas arising in this model. Mutations of the Apc and p53 genes in the regions corresponding to mutation hot spots in human colorectal cancer...
متن کاملMolecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.
Mice deficient in beta(2)-microglobulin and interleukin 2 (beta(2)m(null) x IL-2(null)) spontaneously develop colon cancer in the setting of chronic ulcerative colitis (UC). We investigated mutations of the Apc and p53 genes and microsatellite instability in colonic adenocarcinomas arising in this model. Mutations of the Apc and p53 genes in the regions corresponding to mutation hot spots in hu...
متن کاملMolecular Genetics of Ulcerative Colitis - associated Colon Cancer in the Interleukin 2 - and 2 - Microglobulin - deficient Mouse 1
Mice deficient in 2-microglobulin and interleukin 2 ( 2m null IL2) spontaneously develop colon cancer in the setting of chronic ulcerative colitis (UC). We investigated mutations of the Apc and p53 genes and microsatellite instability in colonic adenocarcinomas arising in this model. Mutations of the Apc and p53 genes in the regions corresponding to mutation hot spots in human colorectal cancer...
متن کاملGenomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia.
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon associated with a high risk of colorectal cancer. This increased cancer risk is thought to result from the cellular damage induced by the inflammatory field. The aim of this study was to determine the pattern and time course of genomic instability occurring in UC-related neoplasia. Sites of cancer, dysplasia, and nondysplasi...
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ورودعنوان ژورنال:
- Gut
دوره 46 3 شماره
صفحات -
تاریخ انتشار 2000